Thermo Fisher Scientific SEMA3F Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total SEMA3F.

Target Information

The semaphorins are a family of proteins that are involved in signaling. All members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]).
Sequence comparisons have grouped the secreted semaphorins into three general classes, all of which also have an immunoglobulin domain.
The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus.
Chicken collapsin contributes to axon pathfinding during development by inhibiting growth cone extension (Luo et al., 1993 [PubMed 8402908]) through interaction with a collapsin response mediator protein (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance-associated UNC33 gene product (MIM 601168).
SEMA3F is a secreted member of the semaphorin III family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.