Thermo Fisher Scientific CD3e Recombinant Rabbit Monoclonal Antibody (SY0239)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Controls: Human thymus tissue lysate, Jurkat cell lysate, human tonsil tissue, human spleen tissue, Jurkat cells
• Subcellular Location: Cell membrane

Target Information

The CD3 subunit complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex. T cell activation through the TCR involves the cytoplasmic tails of CD3 gamma, delta, epsilon, and zeta subunits, which are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.

CD3 subunits have long cytoplasmic tails that associate with signal transduction molecules via a double tyrosine-based motif. CD3 may play a role in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is present on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells. Decreased percentages of T lymphocytes may be observed in certain autoimmune diseases. Genes encoding CD3 epsilon, gamma, and delta are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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