Thermo Fisher Scientific CD74 (B-Cell Marker) Recombinant Rabbit Monoclonal Antibody (CLIP/7023R)

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Does not react with Rat

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The alpha chain gene contains 5 exons:

• Exon 1 encodes the leader peptide
• Exons 2 and 3 encode the two extracellular domains
• Exon 4 encodes the transmembrane domain and the cytoplasmic tail

DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, while the beta chain contains all the polymorphisms specifying the peptide binding specificities.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
The human MHC class II molecules (DR, DQ, and DP loci) bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in initiating immune responses.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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