Thermo Fisher Scientific CD74 (B-Cell Marker) (Transcription Regulator) Monoclonal Antibody (CLIP/6609)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2 µg/mL

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. Within the DR molecule, the beta chain contains all the polymorphisms specifying peptide binding specificities. Hundreds of DRB1 alleles have been described, and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. Three loci—DR, DQ, and DP—encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating the immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.