Thermo Fisher Scientific CD74 (B-Cell Marker) (Transcription Regulator) Monoclonal Antibody (CLIP/6609)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2 µg/mL

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The alpha chain gene contains five exons:

• Exon 1 encodes the leader peptide
• Exons 2 and 3 encode the two extracellular domains
• Exon 4 encodes the transmembrane domain and cytoplasmic tail

DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, with DRB1 containing polymorphisms responsible for peptide-binding specificity.
Hundreds of DRB1 alleles are known, and typing for these polymorphisms is routinely performed for bone marrow and kidney transplantation.

HLA-DR is primarily expressed on antigen-presenting cells such as:

• B lymphocytes
• Monocytes
• Macrophages
• Thymic epithelial cells
• Activated T lymphocytes

Three loci (DR, DQ, and DP) encode the major expressed products of the human class II region.
Human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.