Thermo Fisher Scientific GM-CSF Monoclonal Antibody (MP122E9)
Mouse GM-CSF를 특이적으로 인식하는 Rat IgG2a 단클론 항체로, WB, ELISA, Flow Cytometry, Neutralization 등 다양한 응용에 사용 가능. 인간 GM-CSF와 교차 반응하지 않으며, 고순도의 Protein A/G 정제 및 무보존제 PBS 버퍼로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Flow Cytometry (Flow) | - | View 1 publication |
| ELISA | 0.1–0.4 µg/mL (Detection), 2–8 µg/mL (Capture) | - |
| Neutralization (Neu) | 0.03–0.09 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MP122E9 |
| Immunogen | Yeast-derived recombinant mouse GM-CSF |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609794 |
Product Specific Information
- In Western blots, this antibody does not cross-react with recombinant human GM-CSF.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
The GM-CSF gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated cytokine levels, including GM-CSF, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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