Thermo Fisher Scientific Phospho-IRS1 (Ser323) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated IRS1 at Ser323. Suitable for Western blot and IHC applications. Supplied as unconjugated liquid at 1 mg/mL concentration. Designed for research use to study insulin signaling pathways.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human IRS-1 around the phosphorylation site of Ser323 (P-G-SP-F-R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554887 |
Target Information
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1), and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine, and tyrosine residues in various tissues. Casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser99 is an additional site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser270, Ser374, and Ser641), and the motif around Ser270 is located in the phosphotyrosine binding domain of IRS-1, which is responsible for interaction with the insulin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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