Thermo Fisher Scientific Phospho-IRAK1 (Thr387) Polyclonal Antibody
인간 IRAK1 Thr387 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, 면역세포 내 신호전달 연구에 적합함. ICC/IF 적용 가능하며, 1:100~1:500 희석 사용 권장. 액상 형태로 -20°C 보관, 연구용 전용 제품.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Thr387 (R-G-TP-L-A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554885 |
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways.
It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.
IRAK’s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation.
Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation.
IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus.
This results in the transcriptional activation of type I IFN genes, which drive the cell into an antiviral state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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