Thermo Fisher Scientific CD155 Monoclonal Antibody (2H7CD155), Super Bright 436, eBioscience
CD155 단백질을 인식하는 마우스 모노클로날 항체로, Super Bright 436 형광체로 결합되어 있습니다. Flow Cytometry 분석에 최적화되어 있으며, 405 nm 레이저에서 여기되어 436 nm에서 방출됩니다. 인간 시료에 반응하며, 세포 부착 및 NK 세포 활성 연구에 적합합니다.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.25 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Super Bright™ 436, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H7CD155 |
| Conjugate | Super Bright™ 436 |
| Excitation/Emission Max | 413/431 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2784823 |
Available Formats
Product Specific Information
The monoclonal antibody 2H7CD155 recognizes CD155 (poliovirus receptor), a member of the immunoglobulin superfamily. Four isoforms exist, with alpha and delta forms expressed on monocytes, prostate cancer cells, and neurectodermal or monocytic tumor cell lines. CD155 is also present during mid-gastrulation in embryonic development. It is involved in cell adhesion via interaction with vitronectin and plays a role in NK cell-mediated tumor cell killing. CD226 and CD96 are known ligands for CD155. Blocking of CD155 is under investigation for therapeutic prevention of poliovirus variants.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-diluted and tested on U937 cells at 5 µL (0.25 µg) per test
- Recommended Cell Number: 10⁵–10⁸ cells/test
- Excitation: 405 nm
- Emission: 436 nm
- Laser: Violet Laser
Super Bright 436 can be excited with the violet laser line (405 nm) and emits at 436 nm. Use a 450/50 bandpass filter or equivalent. Ensure the instrument supports this fluorochrome.
When using multiple Super Bright dye-conjugated antibodies, use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize non-specific polymer interactions.
Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.
Target Information
The CD155 gene encodes a transmembrane glycoprotein of the immunoglobulin superfamily. Its extracellular domain mediates cell attachment to vitronectin, and the intracellular domain interacts with dynein light chain Tctex-1/DYNLT1. The gene is primate-specific and acts as a cellular receptor for poliovirus during the first step of viral replication. Multiple transcript variants encoding different isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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