Thermo Fisher Scientific Human ZMIZ1 Synthetic Peptide

Thermo Fisher Scientific Human ZMIZ1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the amino terminus of human ZIMP10.
PEP-1247 can be used as a blocking peptide with polyclonal antibody PA5-21133.

Target Information

Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes.
RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain, and ovaries. Within the brain, the highest expression is in the amygdala.
The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and two proline-rich regions.
A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region.
RAI17 expression is detected in various cancer cell lines and colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples.
In human prostate cancer cells, RAI17 increases the transcriptional activity of AR.
Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.