Thermo Fisher Scientific Human CD244 Synthetic Peptide
Human CD244 단백질의 16개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. PA5-21136 항체의 블로킹 펩타이드로 사용 가능하며, NK 세포 및 T 세포의 SLAMF4 연구에 적합합니다. 정제된 액상 형태로 제공되며, PBS(pH 7.2) 버퍼에 0.1% BSA와 0.02% sodium azide가 포함되어 있습니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the carboxy terminus of human SLAMF4.
PEP-1250 can be used as a blocking peptide with polyclonal antibody PA5-21136.
Target Information
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells and some T cells that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK cells and target cells via CD244 modulates NK-cell cytolytic activity. CD244 interacts with SLAMF2, activating both SLAMF4- and SLAMF2-expressing cells.
Patients with systemic lupus erythematosus have lower SLAMF4 expression on NK cells and monocytes, suggesting SLAMF4 involvement in autoimmune disease pathology. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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