Thermo Fisher Scientific Human PRR5L Synthetic Peptide
Human PRR5L 유래 합성 펩타이드로, 항체 블로킹 실험에 사용 가능. mTORC2 관련 세포 성장 및 사멸 연구에 적합. 고순도 정제, 액상 형태, 인간 반응성. 연구용으로만 사용.
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Thermo Fisher Scientific Human PRR5L Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the center of human PRR5L.
PEP-1243 can be used as a blocking peptide with polyclonal antibody PA5-21129.
Target Information
Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2).
PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2.
Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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