Thermo Fisher Scientific TNFAIP6 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal TNFAIP6 항체로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%) 보장. PBS 및 글리세롤 용액 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminal of Human TNFAIP6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719060 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
The TSG6 gene is transcribed in normal fibroblasts and activated by cytokines TNF alpha and IL-1 via AP-1 and NF-IL6 promoter sites. TSG-6 is a glycoprotein in the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein, and the adhesion receptor CD44. It shares high homology with CD44 in the hyaluronic acid-binding domain.
TSG-6 expression is rapidly induced by TNF alpha, IL-1, and lipopolysaccharide in fibroblasts, mononuclear cells, synovial cells, and chondrocytes. Its presence in synovial fluid suggests a role in rheumatoid arthritis. TSG-6 forms stable complexes with inter-alpha-inhibitor (IαI) components and enhances their inhibitory effect on plasmin, thereby modulating protease activity and inflammation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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