Thermo Fisher Scientific TRAIL-R2 (DR5) Polyclonal Antibody
TRAIL-R2 (DR5) 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며 PBS buffer에 0.02% sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 20 amino acid peptide near the carboxy terminus of human DR5 precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155451 |
Product Specific Information
- Suggested positive control: Hela cell lysate
- Can be used with blocking peptide PEP-0021
- Immunogen located within the last 50 amino acids of DR5
- Predicted molecular weights: ~48 kD and 45 kD
- In Western blot applications, detects bands at 48 kD and 45 kD
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis. It belongs to the TNF-receptor superfamily and transduces apoptotic signals via TNFSF10/TRAIL/APO-2L. FADD adaptor protein is required for DR5-mediated apoptosis.
DR5 overexpression induces apoptosis and activates NF-κB. It is expressed in various cell types, particularly lymphocytes and spleen.
Diseases associated with DR5 dysfunction include squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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