Thermo Fisher Scientific APAF1 Polyclonal Antibody
APAF1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC에 사용 가능. Human, Mouse, Rat 시료 반응. 1 mg/mL 농도의 액상 형태로 제공되며, 항원 친화 크로마토그래피로 정제됨. 세포 사멸 관련 연구에 적합.
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- PA519893
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids near the amino terminus of human Apaf1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152742 |
Product Specific Information
In Western blot applications, this antibody detects a band at approximately 115–130 kDa. A suggested positive control is K562 cell lysate.
Target Information
The APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein includes multiple WD-40 domains, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, it forms an oligomeric apoptosome that activates caspase 9, triggering the apoptotic cascade. Alternative splicing results in several transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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