Thermo Fisher Scientific Phospho-Catenin alpha-1 (Ser641) Polyclonal Antibody
Phospho-Catenin alpha-1 (Ser641) 폴리클로날 항체로, 인산화된 Ser641 위치의 내인성 α-카테닌을 특이적으로 검출합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 인간·마우스 등 다양한 종에 반응합니다. 고순도 정제 및 안정적 액상 형태로 연구용에 적합합니다.
- 카탈로그번호
- PA5105820
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTNNA1 (Accession P35221), corresponding to amino acid residues around phosphorylated Ser641 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817219 |
Product Specific Information
This antibody detects endogenous levels of alpha 1 Catenin only when phosphorylated at Ser641.
Target Information
Alpha 1 Catenin associates with the cytoplasmic domain of various cadherins, forming complexes linked to the actin filament network, which are essential for cadherin-mediated cell adhesion. It can interact with both E- and N-cadherins. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for actin binding, playing a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-105820_Catenin_alpha-1_P35221-1_Rabbit.svg, PA5-105820_Catenin_alpha-1_P35221-1_Rabbit_PDP.jpeg)
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