Thermo Fisher Scientific Phospho-CENTB1 (Ser554) Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Centaurin beta-1 only when phosphorylated at Ser554.

Target Information

ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain that binds phospholipids.
ACAP1 acts as a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) and is required for clathrin-dependent export of proteins from recycling endosomes to the trans-Golgi network and cell surface.
It mediates CENTB1 binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) membranes.
ACAP1 is recruited to PDGF-induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, where its overexpression inhibits ruffle formation.
It is widely expressed in most tissues, with high expression in lung and spleen, and low expression in heart, kidney, liver, and pancreas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-105821_CENTB1_Q15027-1_Rabbit.svg, PA5-105821_CENTB1_Q15027-1_Rabbit_PDP.jpeg)