Thermo Fisher Scientific CD44 Recombinant Rabbit Monoclonal Antibody (SAIC-01B-4D8)
Thermo Fisher의 CD44 Recombinant Rabbit Monoclonal Antibody (SAIC-01B-4D8)는 인간 CD44 항원을 특이적으로 인식합니다. Western blot, ICC/IF, Flow cytometry, ELISA 등에 사용 가능하며, HEK293 세포에서 발현된 재조합 단일클론 항체입니다. 단백질 A로 정제된 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | Assay-dependent |
| Mass Spectrometry (MS) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAIC-01B-4D8 |
| Immunogen | Peptide TFIPVTSAK derived from CD44 (hyaluronic acid receptor mediating cell-cell and cell-matrix interactions), conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074333 |
Product Specific Information
Specificity: Recognises human CD44 (Indian blood group).
Target Information
CD44 is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and epithelial cells of intestine and breast.
It serves as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration.
CD44 plays roles in lymphocyte activation, recirculation, and homing, and may be upregulated in certain carcinomas, possibly linked to metastatic potential.
CD44 is expressed in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes.
Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression upon stimulation.
Transcripts undergo complex alternative splicing, generating multiple isoforms with distinct functions.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be implicated in tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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