Thermo Fisher Scientific GFAP Monoclonal Antibody (OTI4D11), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: Assay-dependent

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

GFAP (Glial fibrillary acidic protein) is a class III intermediate filament protein predominantly expressed in astrocytes and certain astroglia of the central nervous system. It is also found in satellite cells of peripheral ganglia and non-myelinating Schwann cells. Neural stem cells strongly express GFAP, making antibodies to GFAP useful as astrocytic cell markers.
GFAP expression is observed in various brain tumors derived from astrocytic cells, as well as in lens epithelium, Kupffer cells, salivary tumors, and erythrocytes.
GFAP serves as a marker to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene cause Alexander disease, a rare astrocytic disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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