Thermo Fisher Scientific Phospho-IRF3 (Ser385) Polyclonal Antibody
IRF3 단백질의 Ser385 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 검증됨. 고순도(>95%) 항체로 1 mg/mL 농도, PBS/glycerol buffer에 보관. 인간 및 마우스 시료에 반응하며, 바이러스 감염 관련 선천면역 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 | - |
| in situ PLA (PLA) | – | View 1 publication |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human IRF3 around the phosphorylation site of Serine 385 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553722 |
Product Specific Information
- Detects endogenous IRF3 protein at molecular weights of 47 and 55 kDa.
- Purity >95% by SDS-PAGE.
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IRF3 regulates transcription of IFN-alpha, IFN-beta, and interferon-stimulated genes (ISG) by binding to interferon-stimulated response elements (ISRE) in their promoters.
Upon viral infection or toll-like receptor signaling, IRF3 is phosphorylated by IKBKE and TBK1 kinases, leading to dimerization, nuclear localization, and activation of IFN and ISG gene transcription. Mutations in IRF3 can cause acute, infection-induced encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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