Thermo Fisher Scientific Chemerin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1 µg/mL

Neutralization (Neu)

• Tested Dilution: 3–9 µg/mL

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human Chemerin is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs).
Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted.
TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles, and endothelial cells as well as in pancreas, spleen, and intestine.
TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids.
TIG2 is a secreted protein mainly expressed in epidermis, hair follicles, and endothelial cells. It is inhibited in psoriatic lesions and activated by tazarotene in skin rafts and psoriatic epidermis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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