Thermo Fisher Scientific IL4R Polyclonal Antibody
Human IL4R 인식 염소 다클론 항체로 Western blot 및 유세포분석에 적합. 항원 친화 크로마토그래피로 정제되었으며, 보존제 무첨가 동결건조 형태. IL-4 및 IL-13 수용체 연구용으로 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Sf 21-derived recombinant human IL-4 R alpha |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609136 |
Product Specific Information
In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) IL-1 sRI, rhIL-1 sRII, rhIL-2 sR alpha, rhIL-2 sR beta, rhIL-2 sR gamma, rhIL-3 sR alpha, and rhIL-5 sR alpha is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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