Thermo Fisher Scientific NOTCH2 Polyclonal Antibody
Human NOTCH2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 최적화되어 있습니다. Protein A로 정제된 액상형 제품이며, PBS/BSA buffer에 0.05% sodium azide를 포함합니다. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다.
- 카탈로그번호
- PA523455
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 1550–1600 of human NOTCH2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540955 |
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type I transmembrane protein with an extracellular domain containing multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of several distinct domain types.
It functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1, regulating cell-fate determination.
Defects in NOTCH2 are associated with Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, cardiac, skeletal, and ophthalmologic manifestations, as well as distinctive facial features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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