Thermo Fisher Scientific DLL4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 3–6 µg/mL

Product Specifications

Target Information

Delta-like ligand 4 (DLL4), also known as Delta-4, is a homologue of the Drosophila Delta protein and functions as a transmembrane ligand to the Notch1 receptor. DLL4 is expressed in vascular tissues and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF) as a negative feedback regulator to control angiogenic sprouting and promote formation of a differentiated vascular network.

DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer. Inhibition of DLL4 leads to increased vascular proliferation but defective maturation, resulting in decreased tumor growth without apparent toxicity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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