Thermo Fisher Scientific NFkB p50 Polyclonal Antibody

Thermo Fisher Scientific NFkB p50 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Product stable for several weeks at 4°C as undiluted liquid.
• Dilute only prior to immediate use.
• Anti-Human NFkB p50 (NFKB1) may react non-specifically with other proteins.
• Control peptide (code #100-4164p) will compete only with the specific reaction of antiserum with Human NFkB p50 (NFKB1).

Target Information

NF-kB is a nuclear transcription factor activated by various extra- and intracellular stimuli such as cytokines, UV radiation, stress, injury, and bacterial or viral products. It regulates cellular events including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-kB, belongs to the Rel protein family. It is synthesized as a p105 precursor containing an N-terminal conserved RHD region with nuclear localization, DNA-binding, and dimerization domains.
NFKB1 (p50) forms homodimers or heterodimers with p65 to form functional NF-kB. It directs nuclear translocation and DNA binding of NF-kB.
Pathological roles have been suggested in AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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