Thermo Fisher Scientific CABLES1 Polyclonal Antibody
CABLES1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 신경 발달 및 세포 성장 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 550–600 of human Cables1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553430 |
Product Specific Information
This antibody detects endogenous CABLES1 protein at a molecular weight of approximately 67 kDa.
Purity is >95% by SDS-PAGE.
Target Information
CABLES1 (Cyclin-dependent kinase binding protein) enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases such as ABL1 and WEE1.
- Promotes CDK5 activation, essential for neuronal development
- Inhibits CDK2 activity, leading to growth suppression
- Positively influences neuronal outgrowth
- Acts as a regulator in p53/p73-induced cell death pathways
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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