Thermo Fisher Scientific SOX11 Monoclonal Antibody (SOX11-C1), eFluor 660, eBioscience
SOX11 단백질을 인식하는 인간 반응성 단클론 항체로, eFluor 660 형광체로 결합되어 있습니다. 면역조직화학, 면역세포염색, 유세포분석에 적합하며, 651/668 nm 파장에서 안정적인 형광 신호를 제공합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific SOX11 Monoclonal Antibody (SOX11-C1), eFluor 660, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | View 1 publication |
| Flow Cytometry (Flow) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 660 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SOX11-C1 |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574371 |
Additional Formats
- Unconjugated
- Biotin
- Request custom conjugation
Product Specific Information
The monoclonal antibody SOX11-C1 (C1) recognizes human Sox11. Sox11 is a transcription factor belonging to the SOX (sex determining region Y-related HMG Box) family. It is expressed during embryonic development in the central nervous system and plays roles in neuronal maturation and epithelial-mesenchymal interactions. Sox11 is required for the survival of neuronal and mesenchymal progenitor cells.
Sox11 expression is observed in mantle cell lymphoma (MCL), subsets of hairy cell leukemias, Burkitt lymphomas, and B cell lymphoblastic leukemias, but not in other B cell lymphomas or normal B lymphocytes. It is also expressed in epithelial ovarian cancer and gliomas.
Applications Reported: Suitable for immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections, immunocytochemistry, and flow cytometric analysis.
Applications Tested: Tested in IHC using human tissue at ≤10 µg/mL. Antibody titration is recommended for optimal assay performance.
Fluorophore Information:
eFluor® 660 is a replacement for Alexa Fluor® 647. Emission at 659 nm, excitation at 633 nm (red laser). Ensure instrument compatibility.
Excitation/Emission: 633–647 nm / 668 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
This intronless gene encodes a member of the SOX family of transcription factors involved in embryonic development and cell fate determination. The encoded protein acts as a transcriptional regulator through complex formation with other proteins and may function in the developing nervous system and tumorigenesis.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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