Thermo Fisher Scientific ROR2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors. It is involved in early chondrocyte formation, cartilage, and growth plate development.
This protein is highly expressed during early embryonic development, with expression levels dropping around day 16 and remaining low in adult tissues.

Defects in ROR2 are associated with:

• Brachydactyly type B1 (BDB1): An autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails.
• Robinow syndrome (RRS): A recessive skeletal dysplasia with limb bone shortening, spinal defects, brachydactyly, and facial dysmorphism.

The protein contains:

• 1 frizzled (FZ) domain
• 1 immunoglobulin-like C2-type domain
• 1 kringle domain

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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