Thermo Fisher Scientific NEDD5 Polyclonal Antibody
NEDD5(Septin 2) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. 단백질 A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Septin 2/NEDD5, amino acids 251–350 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Septin 2 is a filament-forming cytoskeletal GTPase required for normal organization of the actin cytoskeleton. It plays a role in the formation of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, facilitating vesicle transport, and preventing MAP4 binding to tubulin. Septin 2 is essential for mitotic progression, forming a scaffold at the midplane of the mitotic spindle to maintain CENPE localization at kinetochores and ensure chromosome congression. During anaphase, it is involved in chromosome segregation and spindle elongation. Additionally, Septin 2 contributes to ciliogenesis and collective cell movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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