Thermo Fisher Scientific RYR2 Polyclonal Antibody
RYR2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC에 사용 가능. Human, Mouse, Rat에 반응하며, 무보존제 동결건조 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of mouse Ryanodine receptor 2 (RYR2) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: RYR2.
Target Information
Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle.
DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are key components of intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca²⁺ from internal stores.
The alpha1-subunit of DHPR contains a cytoplasmic loop involved in interactions with RyR.
Phosphorylation of the DHPR alpha1-subunit is thought to influence DHPR–RyR functional interaction.
Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis and loss of skeletal muscle activity.
Cells lacking RyR also lack excitation-contraction coupling and show reduced Ca²⁺ current density.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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