Thermo Fisher Scientific Fibronectin Monoclonal Antibody (FN1, 2948)
인간 Fibronectin(FN1)을 인식하는 단클론 항체로, IHC(P) 및 Peptide Array에 적합합니다. Protein A/G 정제, 무보존제 액상 형태이며, 세포 부착 및 이동 연구에 활용됩니다. Thermo Fisher Scientific의 고품질 연구용 항체입니다.
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- 2335-MSM8-P1ABX
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Applications and Tested Dilution
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FN1, 2948 |
| Immunogen | Recombinant fragment (around aa 467–595) of human fibronectin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is tested in direct ELISA.
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also present as a soluble plasma protein.
Fibronectin consists of repeating modules forming domains for interaction with itself, matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays a key role in cell adhesion, migration, wound healing, blood coagulation, host defense, and metastasis. Overexpression is often observed in non-small cell lung carcinoma, enhancing tumorigenicity and resistance to apoptosis. The FN1 gene undergoes alternative splicing, potentially generating up to 20 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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