Thermo Fisher Scientific PKC alpha Monoclonal Antibody (MC5), Biotin
PKC alpha 단백질을 표적하는 Mouse monoclonal antibody (Clone MC5). ELISA, IP, WB 등 다양한 응용에 사용 가능. Biotin 결합형으로 높은 특이성과 재현성을 제공. Human, Mouse, Bovine 시료에 반응하며 Protein G로 정제됨.
- 카탈로그번호
- MA517705
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MC5 |
| Immunogen | Mouse monoclonal antibodies raised against purified bovine brain protein kinase C alpha |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539095 |
Product Specific Information
MA5-17705 targets PKC alpha in ELISA, IP, and WB applications and shows reactivity with Human samples.
The immunogen is mouse monoclonal antibodies raised against purified bovine brain protein kinase C alpha.
Target Information
The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways.
In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent.
Protein kinase C (PKC) can be activated by calcium and diacylglycerol, phosphorylating various protein targets involved in signaling pathways.
PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters.
Each member has distinct expression profiles and roles in cells. PKC alpha is implicated in cell adhesion, transformation, cell cycle checkpoint, and volume control.
Knockout studies in mice suggest PKC alpha regulates cardiac contractility and Ca²⁺ handling in myocytes.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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