Thermo Fisher Scientific CD21 Monoclonal Antibody (21A/5), Biotin
Human CD21 인식 단일클론 항체로 FACS 및 IHC(F) 실험에 적합. Biotin 결합형으로 단백질 G 정제. PBS/BSA 완충액에 보관되며, 4°C 단기 보관 및 -20°C 장기 보관 가능. CD21 관련 면역학 연구에 활용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 0.5 µg/1x10^6 cells | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 21A/5 |
| Immunogen | Mouse monoclonal antibodies raised against human CD21 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539098 |
Additional Formats
Product Specific Information
MA5-17708 targets CD21/CR2 in FACS and IHC (F) applications and shows reactivity with Human samples.
The MA5-17708 immunogen is mouse monoclonal antibodies raised against human CD21.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement-activating surfaces or antigens.
CD21 plays key roles in:
- Uptake and retention of immune complexes
- Survival of memory B cells
- Development and maintenance of the humoral immune response
Additionally, CD21:
- Serves as a receptor for Epstein-Barr virus
- Involves in targeting prions to follicular dendritic cells
- Facilitates neuroinvasion following peripheral prion exposure
- Exists in soluble form (sCD21), retaining ligand-binding ability
- Functions as receptor for C3d, C3dg, iC3b complement components, EBV, and IFNα
- Associates with CD23, CD19, CD81, and Leu13 forming a signal-transduction complex for B cell activation
Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different isoforms of CD21 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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