Thermo Fisher Scientific CD21 Monoclonal Antibody (21A/5), Biotin

Applications

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

MA5-17708 targets CD21/CR2 in FACS and IHC (F) applications and shows reactivity with Human samples.
The MA5-17708 immunogen is mouse monoclonal antibodies raised against human CD21.

Target Information

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement-activating surfaces or antigens.
CD21 plays key roles in:

• Uptake and retention of immune complexes
• Survival of memory B cells
• Development and maintenance of the humoral immune response

Additionally, CD21:

• Serves as a receptor for Epstein-Barr virus
• Involves in targeting prions to follicular dendritic cells
• Facilitates neuroinvasion following peripheral prion exposure
• Exists in soluble form (sCD21), retaining ligand-binding ability
• Functions as receptor for C3d, C3dg, iC3b complement components, EBV, and IFNα
• Associates with CD23, CD19, CD81, and Leu13 forming a signal-transduction complex for B cell activation

Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different isoforms of CD21 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.