Thermo Fisher Scientific P53 Monoclonal Antibody (UMAB19), UltraMAB

Applications and Tested Dilutions

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. p53 upregulates stress response genes such as p21waf1, leading to G1 or G2/M arrest.

Structurally, p53 contains:

• N-terminal transactivation domain
• Central DNA-binding domain
• Oligomerisation domain
• C-terminal regulatory domain

Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a vital role in preventing proliferation of damaged cells and acts as an anticancer agent. It is also linked to aging, oxidative stress, and learning and memory deficits due to its regulation of long-term potentiation (LTP).

Mutations in TP53 are common in human cancers, leading to loss of DNA binding and tumor suppressor activity. Both somatic and germline mutations (e.g., Li-Fraumeni syndrome) have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.