Thermo Fisher Scientific MEF2C Monoclonal Antibody (UMAB17), UltraMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

MEF2C is a transcription activator that binds to the MEF2 element in the regulatory regions of many muscle-specific genes. It controls cardiac morphogenesis and myogenesis, and is involved in vascular development.
It plays an essential role in hippocampal-dependent learning and memory by regulating excitatory synapses and synaptic transmission.
MEF2C is crucial for normal neuronal development, distribution, and electrical activity in the neocortex, and is necessary for proper development of megakaryocytes, platelets, and bone marrow B lymphopoiesis.
It supports B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens, and normal induction of germinal center B cells.
Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.