Thermo Fisher Scientific INSM1 (Pan-Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody (INSM1/8122R)
INSM1 단백질을 표적하는 재조합 토끼 단클론 항체로, 신경내분비 종양 마커 연구에 적합. 파라핀 또는 PFA 고정 조직의 면역조직화학(IHC) 분석에 사용. 고순도 Protein A/G 정제, 보존제 무첨가 PBS 용액 형태. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | INSM1/8122R |
| Immunogen | Recombinant fragment (around aa1–300) of human INSM1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Target Information
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor initially identified from an insulinoma cDNA library, expressed in the developing nervous system. It appears as early as E9.5 in mice in the forebrain, midbrain, hindbrain, spinal cord, retina, and olfactory bulb. IA-1 functions as a transcriptional repressor and participates in several signaling pathways, including Notch, sonic hedgehog, and Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including most neuroendocrine tumors and nearly all small cell lung carcinomas, suggesting its importance as a cancer therapy target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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