Thermo Fisher Scientific INSM1 (Pan-Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody (INSM1/8149R)
INSM1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, 신경내분비 종양 표지 연구에 적합합니다. 파라핀 절편 및 PFA 고정 조직에서 사용 가능하며, 높은 특이성과 재현성을 제공합니다. 단백질 A/G로 정제된 액상 항체로, 보존제가 포함되어 있지 않습니다.
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Applications and Tested Dilution
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | INSM1/8149R |
| Immunogen | Recombinant fragment (around aa1–300) corresponding to the N-terminus of human INSM1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor initially identified from an insulinoma cDNA library and expressed in the developing nervous system. In mice, IA-1 is expressed as early as E9.5 in the forebrain, midbrain, hindbrain, spinal cord, retina, and olfactory bulb. It functions as a transcriptional repressor and participates in several signaling pathways, including Notch, sonic hedgehog, and Ngn3, during pancreatic endocrine cell differentiation. IA-1 is also expressed in various tumors, including most neuroendocrine tumors and nearly all small cell lung carcinomas, suggesting its potential as a cancer therapy target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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