
Thermo Fisher Scientific HIP2 Polyclonal Antibody
HIP2 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 인간에 반응하며, 다른 종에서도 예측 반응합니다. 고순도 액상 형태로 안정적인 신호 검출을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (SWDVETATELLLSN) corresponding to the C-terminus amino acids of UBE2K (aa 187–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10980306 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 2,000.
Target Information
HIP2 (UBE2K) accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It catalyzes the synthesis of Lys-48-linked polyubiquitin chains, mediating selective degradation of short-lived and abnormal proteins such as ER-associated misfolded proteins. Ubiquitinates huntingtin and may suppress apoptosis of lipid-bearing macrophages through p53/TP53 degradation. Involved in ubiquitination and proteolytic processing of NF-kappa-B and supports ubiquitination of NFKB1. During viral infections, it may participate in MHC class I heavy chain degradation and RB1 degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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