Thermo Fisher Scientific IL3RA/CD123 (Acute Myeloid Leukemia Marker) Recombinant Mouse Monoclonal Antibody (rIL3RA/9212)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b, kappa

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

rIL3RA/9212

Immunogen

Recombinant fragment of human IL3RA protein (around aa 26-171). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD123,uniProtId:P26951-1,ncbiNodeId:9606,antigenRange:26-171,antigenLength:378,antigenImageFileName:3563-MSM8-P0_CD123_P26951-1_House_mouse.svg,antigenImageFileNamePDP:3563-MSM8-P0_CD123_P26951-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control: lymph node or stomach RPMI-8226 or HDLM-2 cells. Human tonsil THP-1

Cellular Location: Cell Surface. Cytoplasm.

Target Information

IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. IL-3Ra is responsible for the transmission of signal of Interleukin-3. IL-3Ra and IL-3Rb chain heterodimerization is induced by Interleukin-3, which is required for receptor activation but not high affinity binding. IL-3Ra is also reported that IL-3Ra subunits are overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells and are thus potential targets for novel therapeutic agents.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.