Thermo Fisher Scientific MYH9 Polyclonal Antibody
Human MYH9 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관됩니다. 다양한 종에 예측 반응성을 보이며 연구용으로 적합합니다.
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Applications
- Western Blot (WB): 1:500–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human MYH9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.59 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792929 |
Product Specific Information
- Keep as a concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%).
- Positive Controls: 293T, A431, HeLa, HepG2, MYH9-EGFP-transfected 293T.
- Centrifuge briefly prior to opening the vial.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a key component of the actin cytoskeleton involved in cellular processes such as migration, adhesion, division, and shape maintenance.
It spans over 106 kb and includes 41 exons, producing a 1,960 amino acid protein forming a hexameric complex with light chains.
Mutations in MYH9 cause autosomal dominant MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, which are associated with macrothrombocytopenia and may lead to hearing loss, renal failure, or cataracts.
MYH9 is also essential for hematopoiesis, maintaining hematopoietic stem and progenitor cell survival; its loss disrupts normal blood cell development and can lead to bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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