Thermo Fisher Scientific Contactin 2 Polyclonal Antibody
Rabbit polyclonal antibody against human Contactin 2. Validated for WB and IHC applications. Lyophilized form for stable long-term storage. Specific for contactin-2, a neuronal cell adhesion molecule involved in axon guidance. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 650–700 of human Contactin 2 conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C for short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: contactin-2.
Target Information
Contactin 2 (CNTN2), also known as transiently-expressed axonal glycoprotein (AXT, TAX, TAX1, TAG-1, axonin 1), is a neuronal cell adhesion molecule (CAM) that influences axon formation in the developing nervous system.
It belongs to the immunoglobulin superfamily (IgSF) and contains:
- A glycosylphosphatidylinositol (GPI) anchor
- Six immunoglobulin (Ig)-like domains
- Four Fibronectin type III (FNIII)-like domains
Contactin 2 is expressed predominantly during neural development on axonal membranes to guide commissural axons.
It binds NgCAM in cis (same membrane) and forms heterophilic (Contactin 2/NgCAM, Contactin 2/NrCAM) and homophilic (Contactin 2/Contactin 2) interactions.
Binding sites are localized to:
- Ig domains 1–4 (heterophilic)
- FNIII domain (homophilic)
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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