Thermo Fisher Scientific CEP164 Polyclonal Antibody
CEP164 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 합성 펩타이드(aa 650–700)를 면역원으로 사용하며, 인간 시료에 반응합니다. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적입니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 650–700 of human CEP164 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CEP164.
Target Information
CEP164 was initially identified as a centrosomal protein, but subsequent studies revealed its role in the formation of primary cilia — the microtubule-based sensory antennae projecting from the surface of many eukaryotic cells.
It also functions in DNA damage response as a mediator protein interacting with ATR and ATM, which trigger cellular responses including DNA damage-induced cell cycle checkpoints.
CEP164 is phosphorylated upon replication stress, UV radiation, and ionizing radiation. Silencing of CEP164 significantly reduces DNA damage-induced phosphorylation of several proteins in the DNA damage signaling cascade and compromises cell survival after UV damage.
At least two isoforms of CEP164 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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