Thermo Fisher Scientific CDNF Polyclonal Antibody
CDNF 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunohistochemistry에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관을 권장합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 70–130 of human CDNF conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: CDNF.
Target Information
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and is highly homologous to mesencephalic-astrocyte-derived neurotrophic factor.
CDNF is expressed at higher levels in tissues such as heart, skeletal muscle, and testes than in the brain. Similar to glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent 6-hydroxydopamine (6-OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease. Furthermore, CDNF was able to restore dopaminergic function and prevent degeneration of dopaminergic neurons in the substantia nigra, suggesting potential therapeutic relevance for Parkinson’s disease. At least two isoforms of CDNF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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