Thermo Fisher Scientific CD74 Monoclonal Antibody (3D7), PerCP

Applications and Tested Dilutions

Product Specifications

Additional Formats

• APC
• FITC
• Request custom conjugation

Product Specific Information

A 1:1,000 dilution of MA5-45383 was sufficient for detection of CD74 in 15 µg of B-Cell Lymphoma cell line Raji by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody. Detects approximately 33 kDa protein.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail. DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5 and lacks polymorphisms in the peptide-binding region. The beta chain contains polymorphisms determining peptide binding specificity. HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. The DR, DQ, and DP loci encode the major expressed products of the human class II region, which bind intracellularly processed peptides and present them to T-helper cells, playing a key role in immune response initiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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