Thermo Fisher Scientific pro BDNF Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in mouse and zebrafish and shares 96% identity with the human sequence.
• Specificity: proBDNF.

Target Information

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family.
BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form.

BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor p75-NTR has also been demonstrated.

BDNF promotes neuronal survival and differentiation and plays a critical role in memory formation and synaptic regulation. Expression of BDNF is reduced in both Alzheimer's and Huntington's disease patients and may play a role in stress response regulation and mood disorder biology.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.