Thermo Fisher Scientific pro BDNF Polyclonal Antibody
proBDNF 단백질을 인식하는 Sheep polyclonal 항체로, Western blot 및 IHC에 사용 가능. Mouse와 Rat에 반응하며, PBS 기반으로 보존. 신경영양인자 연구 및 BDNF 관련 신경생물학 연구에 적합.
- 카탈로그번호
- OSB00014G-500UG
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat proBDNF conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and zebrafish and shares 96% identity with the human sequence.
- Specificity: proBDNF.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family.
BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form.
BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor p75-NTR has also been demonstrated.
BDNF promotes neuronal survival and differentiation and plays a critical role in memory formation and synaptic regulation. Expression of BDNF is reduced in both Alzheimer's and Huntington's disease patients and may play a role in stress response regulation and mood disorder biology.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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