Thermo Fisher Scientific TNF alpha Recombinant Rabbit Monoclonal Antibody (HL2361)
Recombinant rabbit monoclonal antibody specific for human TNF alpha. Validated for IHC (Paraffin) and ELISA applications. Produced in HEK293 cells and purified via Protein A. Supplied in PBS without preservative, 1 mg/mL concentration. Suitable for san...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL2361 |
| Immunogen | Full length human TNF alpha recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093034 |
Product Specific Information
This product can be used in Sandwich ELISA to detect TNF alpha using MA5-50505 as a capture antibody and MA5-50504 as a detection antibody.
Target Information
TNF alpha is a multifunctional proinflammatory cytokine belonging to the tumor necrosis factor (TNF) superfamily. It is primarily secreted by macrophages and binds to receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha regulates immune cell activity, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
It exists as multimers of two, three, or five noncovalently linked units and shows a single 17 kDa band on SDS-PAGE under non-reducing conditions. Knockout studies in mice suggest neuroprotective functions, and TNF alpha can induce tumor necrosis when injected into tumor-bearing mice. It plays key roles in immune responses to bacterial, viral, parasitic, and certain fungal infections, as well as in tumor necrosis. TNF alpha is implicated in autoimmune diseases, insulin resistance, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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