Thermo Fisher Scientific Phospho-beta Catenin (Tyr142) Polyclonal Antibody
Phospho-beta Catenin (Tyr142) 항체로, 인산화된 beta Catenin의 내인성 수준을 검출합니다. Western blot 및 ICC/IF에 적합하며, 사람, 마우스, 랫드 등 다양한 종에 반응합니다. Rabbit Polyclonal IgG 형태로, 액상 1 mg/mL 농도로 제공됩니다. 연구용 전용 시약입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTNNB1 (Accession P35222), corresponding to amino acid residues around phosphorylated Tyr142 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817238 |
Product Specific Information
This antibody detects endogenous levels of beta Catenin only when phosphorylated at Tyr142.
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signal transduction. It interacts with E-cadherin and alpha-catenin, linking cell adhesion complexes to the actin cytoskeleton. Beta-catenin also participates in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless, influencing cell growth and morphogenesis.
It is expressed in various cell types, including hair follicle and epithelial cells. Dysregulation of beta-catenin has been implicated in multiple cancers such as pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of genes like cyclin D and c-myc that drive cell proliferation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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