Thermo Fisher Scientific Phospho-ATM (Ser367) Polyclonal Antibody
ATM 단백질의 인산화된 Ser367 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 인간, 생쥐 및 비인간 영장류 시료에서 반응. DNA 손상 반응 연구 및 세포주기 조절 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATM (Accession Q13315), corresponding to amino acid residues around phosphorylated Ser367 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817236 |
Product Specific Information
This antibody detects endogenous levels of ATM only when phosphorylated at Ser367.
Target Information
Ataxia-telangiectasia Mutated (ATM) belongs to the PI3/PI4 kinase family. It plays a critical role in the repair of double-stranded DNA breaks caused by ionizing radiation and other mutagens. The ATM gene encodes a protein kinase that phosphorylates multiple downstream targets such as P53, Mdm2, BRCA1, and SMC1, which are key regulators of the cell cycle.
ATM is autophosphorylated and activated in response to DNA damage, initiating a cascade of kinase reactions that regulate cell cycle checkpoints, apoptosis, and DNA repair. Mutations in ATM cause ataxia-telangiectasia, a rare recessive disorder characterized by neurodegeneration, immune deficiency, and increased cancer susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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