Thermo Fisher Scientific IFNAR1 Polyclonal Antibody
IFNAR1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA에 사용 가능. Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 470–557 of human IFNAR1 (NP_000620.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.6 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914224 |
Product Specific Information
- Positive test controls: SP2/0, A-549, Mouse brain
- Target location: Membrane, Single-pass type I membrane protein
Immunogen sequence:
PSLKPSSSID EYFSEQPLKN LLLSTSEEQI EKCFIIENIS TIATVEETNQ TDEDHKKYSS QTSQDSGNYS NEDESESKTS EELQQDFV
Target Information
Interferons are widely used therapeutic agents because of their antitumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon Receptor (IFNAR1). Downregulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This downregulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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