Thermo Fisher Scientific IRF3 Monoclonal Antibody (OTI4D4), TrueMAB
IRF3 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF, Flow Cytometry 등에 사용 가능. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용. 선천면역 반응 연구 및 IFN 신호전달 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D4 |
| Immunogen | Full length human recombinant protein of human IRF3 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses.
It plays a central role in innate immunity against DNA and RNA viruses by regulating transcription of type I IFN genes (IFN-α and IFN-β) and IFN-stimulated genes (ISG) via binding to interferon-stimulated response elements (ISRE) in their promoters.
IRF3 is activated through phosphorylation by IKBKE and TBK1 kinases, leading to dimerization, nuclear translocation, and activation of IFN and ISG transcription.
Mutations in IRF3 can be associated with acute infection-induced encephalopathy.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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